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Previous research from Lund University has shown that diabetes can be divided into five groups with different disease progression. A new study published in Nature Genetics demonstrates that there are also genetic differences between different groups of patients. An important goal of the research is to contribute with knowledge that will enable tailored treatments of patients with type 2 diabetes.
A lot of research explains which diets may reduce the risk of developing type 2 diabetes. Much research remains to be done about how our genes respond to the foods we eat. A new study led by researchers at Lund University adds to evidence that variations in the AMY1 gene may affect the way the body breaks down starchy foods. Unhealthy food habits are risk factors for developing type 2 diabetes. An
https://www.medicine.lu.se/article/bread-study-examines-role-genes-breaking-down-food - 2025-11-17
...showing that competitors in the Vasaloppet cross-country ski race run a lower risk of suffering from anxiety than the general population. Your results have been reported by the New York Times, CNN and many other international news outlets. Published in September last year, the article Physical Activity Is Associated With Lower Long-Term Incidence of Anxiety in a Population-Based, Large-Scale St
Immune Thrombocytopenia, ITP, is an autoimmune bleeding disorder that is still treated with immunosuppressive drugs that cause serious side effects. Professor John Semple’s laboratory studies the pathophysiological mechanisms behind this disease and together with Dr. Drew Provan, London, UK, has recently published the newest ideas on pathological mechanisms and therapies for the treatment and mana
https://www.medicine.lu.se/article/new-therapies-itp - 2025-11-17
Researchers in Lund have discovered an antitoxin mechanism that seems to be able to neutralise hundreds of different toxins and may protect bacteria against virus attacks. The mechanism has been named Panacea, after the Greek goddess of medicine whose name has become synonymous with universal cure. The understanding of bacterial toxin and antitoxin mechanisms will be crucial for the future success
https://www.medicine.lu.se/article/new-multipurpose-switch-inhibiting-bacterial-growth - 2025-11-17
In recent years, great advances have been made in the development of new successful immunotherapies to treat cancer. CAR T-cell therapy and antibody treatments are two types of targeted immunotherapies that have revolutionised areas of cancer care. However, there are still significant challenges in the identification of cancer cell surface proteins as targets for immunotherapies. A research group
https://www.medicine.lu.se/article/new-precision-technology-immunotherapy - 2025-11-17
1) We found 15 national/regional registries of congenital heart disease worldwide. 2) Registry coverage ranged from 25 to 100% of all eligible cases. 3) The best registries contain demographic, clinical, physical, and laboratory data. 4) Regular verification is essential for quality data and valid statistical findings. Read the paper at https://www.sciencedirect.com/science/article/pii/S0167527321
Quantitative bias analyses allow researchers to adjust for uncontrolled confounding, given specification of certain bias parameters. When researchers are concerned about unknown confounders, plausible values for these bias parameters will be difficult to specify. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/09000/The_Importance_of_M…
https://www.lupop.lu.se/article/importance-making-assumptions-bias-analysis - 2025-11-17
The benefits of using data from national registers as endpoints in epidemiological studies include faster, less resource-intensive access to nationwide data and considerably lower loss to follow-up, compared to manual data collection in a limited geographical area. Read the paper at https://www.dovepress.com/validating-acute-myocardial-infarction-diagno…
The integrative data approach is an effective way to conduct cancer research assessing multilevel factors on cancer outcomes among small populations. Read the paper at https://cebp.aacrjournals.org/content/30/8/1506.long
This first publication of the Austrian Society of Esophageal Surgery shows that the outcome of esophageal surgery for cancer in Austria compares well with that of renowned international centers. However, a more comprehensive approach including as many national centers as possible will improve outcome research, offer quality management, and improve patient safety. The study group invites all Austri
https://www.lupop.lu.se/article/esophageal-resection-austria-preparing-national-registry - 2025-11-17
The CARTR Plus registry is a robust resource for ART data in Canada. It provides easily accessible aggregated data for Canadian fertility clinics, and it contains data that are internationally comparable. Read the paper at https://academic.oup.com/hropen/article/2020/3/hoaa022/5848715
https://www.lupop.lu.se/article/cartr-plus-creation-art-registry-canada - 2025-11-17
Parameters representing adjusted treatment effects may be defined marginally or conditionally on covariates. The choice between a marginal or covariate-conditional parameter should be driven by the study question. However, an unappreciated benefit of marginal estimators is a reduction in susceptibility to finite-sample bias relative to the unpenalized maximum likelihood estimator of the covariate-
https://www.lupop.lu.se/article/decreased-susceptibility-marginal-odds-ratios-finite-sample-bias - 2025-11-17
Confounding, selection bias, and measurement error are well-known sources of bias in epidemiologic research. Methods for assessing these biases have their own limitations. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/09000/Multiple_bias_Sensi…
https://www.lupop.lu.se/article/multiple-bias-sensitivity-analysis-using-bounds - 2025-11-17
Monitoring survival in cancer is a common concern for patients, physicians, and public health researchers. The traditional cohort approach for monitoring cancer prognosis has a timeliness problem. In this paper, we propose a survivorship-period-cohort (SPC) model for examining the effects of survivorship, period, and year-of-diagnosis cohort on cancer prognosis and for predicting future trends in
Life-course epidemiology is useful for describing and analyzing complex etiological mechanisms for disease development, but existing statistical methods are essentially confirmatory, because they rely on a priori model specification. Read the paper at https://academic.oup.com/aje/article/190/9/1898/6189737
https://www.lupop.lu.se/article/data-driven-model-building-life-course-epidemiology - 2025-11-17
Although the need for addressing matching in the analysis of matched case-control studies is well established, debate remains as to the most appropriate analytical method when matching on at least 1 continuous factor Read the paper at https://academic.oup.com/aje/article/190/9/1859/6162924
https://www.lupop.lu.se/article/matched-versus-unmatched-analysis-matched-case-control-studies - 2025-11-17
In the causal mediation framework, several parametric-regression–based approaches have been introduced in the last decade for estimating natural direct and indirect effects. For a binary outcome, a number of proposed estimators use a logistic model and rely on specific assumptions or approximations that may be delicate or not easy to verify in practice. Read the paper at https://academic.oup.com/a
Improvements in the treatment of cystic fibrosis (CF) have resulted in longer survival and an increased focus on optimising daily functioning with the condition. Patient- reported outcome measures (PROMs) are valuable tools in evaluating the health- related quality of life of persons with chronic diseases. Read the paper at https://bmjopenrespres.bmj.com/content/bmjresp/8/1/e000927.full.pdf
https://www.lupop.lu.se/article/acceptability-patient-reported-outcome-measures-proms-cystic-fibrosis-data-registry - 2025-11-17
Confounding by comorbidities is of concern in many epidemiological studies. To take this into account a common strategy is to calculate each participant’s Charlson Comorbidity Index (CCI) and use this for adjustment in regression analyses. Various CCI adjustment strategies are possible, and it is unclear, which is preferable. Read the paper at https://link.springer.com/article/10.1007%2Fs10654-021
